Huntingdon’s Disease

The topic of this report is the Huntingdon’s Disease. Begin with the gene, what are the sequence variants that are found in patients, how these sequence variants affect production of RNA and / or subsequent protein structure and function, how the change in protein structure or abundance affects the rate of the respective reaction or process, how the respective function or process fits into cell function (i.e. if it is an enzyme, what is the purpose of the pathway to which the enzyme belongs on cell function), why reduction in this function causes issues within cells, how this process is cell type specific so only certain tissues are affected, and finally how the pattern of tissues being affected fits with the pattern of symptoms in patients. In other words, can a chain of cause and effect links connect the mutations in genomic DNA and the phenotype of the disease? Please use scientific journal articles and not websites as your primary source of information. The reports should center on biochemistry and not pathology. In addition to the content, the quality of writing will also be evaluated. Ideally, the reports will be well organized with a logical flow of information. Avoid presenting the same information twice. Be sure to check for spelling and grammatical errors. This report paper will mostly focus on the biochemistry behind the Huntingdon’s disease.It needs to have 10 sources and please use scientific journal articles and not websites as the primary source of information. please make sure no plagiarism takes place.

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