This is a research paper on progressive supranuclear palsy . It has to be a psychological reason behind why I choose this topic. For example, social media when it comes social anxiety. I was coming up with medical reasons and now I am in too deep and need an A.
Below is my literature review.
While there has been many research on progressive supranuclear palsy (PSP) not too many took the approach to look at the level of pain. Let us first define what progressive supranuclear palsy is. PSP is a neurological disorder that causes problems with balance, walking, vision, speech, swallowing, personality, and cognition. Symptoms are caused by the deterioration of cells in the areas of the brain that control body movements and thinking. Twenty-eight patients with PD (43%) were on regular analgesia with nine patients (15%) taking neuropathic pain treatments (Gabapentin, Pregabalin, or Amitripty- line). Eleven patients with MSA (52%) were on regular analgesia and four patients were taking neuropathic pain treatments (19%). Five patients with PSP were using reg- ular analgesia (31%) and one patient was on amitripty- line. There was no significant statistical difference between these proportions. The distribution of pain was similar between groups with lower limb pain being the most common followed by upper limb pain, neck pain, and back pain. Bilateral shoulder pain (coat-hanger pain) was similarly prevalent in MSA and PD.
Beiske, A. G., J. H. Loge, A. Ronningen, and E. Svensson. 2009. Pain in Parkinson’s disease: prevalence and characteristics. Pain 141:173–177.
While there has been much research of progressive supranuclear palsy (PSP), few researchers have taken into consideration of the caregiver. Schmotz (2017) introduces that the caregivers of patients with PSP ae known to suffer from multiple stress factors which are comparable with ones that can be found in Alzheimer. Throughout the literature evidence has shown the severity of the disease on the caregiver. Burrell (2014) Caregivers of patients with PSP are two times more likely to have depression in studies concerning parkinsonian syndrome in earlier stages. However, in an era where studies are done every day to find the why.
Burrell J, Hodges J, Rowe J. Cognition in corticobasal syndrome and progressive supranucler palsy; A review. Movement Disorders. 2014;29(5):684-693.
While there has been much research of progressive supranuclear palsy (PSP), the current study sought to address these issues by examining the cognitive profiles of PSP patients not performing within the dementia range (Keith-Rokosh 2008). What would you do for your loved one?
When one gets sick with a disease with no cure like PSP no one ever seems to think of the people who cannot afford to keep up with the medicine, insurance, and doctor bills. They were even able to find cases where a man lost his job therefor lost his insurance. Two months into the new year he finds out that he has less than a year to live. When you have a moment to think of your living situation would one try to do the best they could for their life? There would be family members would want the best no matter the cost and in today’s world money still talks. No one ever just tells you what the signs are like how losing your balance is the start of what one needs to look out for. Even if one wonders what their brain has already been trying to tell you by sending signals to one’s body. Although the cause of PSP is unknown does not mean the doctors do not know what signs to look for or symptoms.
As physical and mental debilities progressively manifest in PSP, the physician, family, and patient face decisions on how to manage terminal neurodegenerative disease. Many researchers never thought about the feelings that go with a loved one having a disease with no cure. While we are focusing on the damage that goes with taking care of someone who is ill. In addition, when it comes to family, that will be your best support alongside with Hospice.
Keith-Rokosh J, Ang L. Progressive Supranuclear Palsy: A Review of Co-existing Neurodegeneration. Can J Neurol Sci.
Many recent studies have focused on the problem of Progressive supranuclear palsy (PSP), but the literature was able dive more into the disease itself and rehabilitation strategies. A study conducted in Olmsted County, Minn, between the years of 1976 and 1990 showed an average annual incidence rate (new cases per 100,000 person-years) of 5.3.^5 All cases were reported between the ages of 50 to 99 years; there were no cases before 50 years of age. More recent estimates from the United Kingdom have revealed that the disease is more common than previously considered, with a crude prev- alence of 6.5 cases per 100,000 people. The studies used detailed methods for case identification to ensure a reliable prevalence estimate and showed that the true incidence of PSP may be masked by misdiagnosed cases (Litvan 2006).
1 Litvan I. Diagnosis and management of progressive supranuclear palsy. Semin Neurol. 2001;21:41-48.
While there has been much research on progressive supranuclear palsy, not many have been researching on the exercise and structured physical activity for people with PSP. Two researchers (SCS and CB) independently conducted an iterative, step-by-step thematic analysis of the de-identified transcripts by using an inductive method [41, 43, 44, 48]. Tran- scripts were read several times to ensure familiarity. Data were coded and compared, category- razed into clusters of meaning according to similarities. Each researcher independently developed preliminary themes by using descriptive content analysis and conducted douc- mended video-conferencing and face-to-face meetings, followed by confirmation emails, until consensus was reached for the final set of themes and sub-themes. Representative quotations for each theme were selected and pooled together to support the identified themes. A coding- tree is available from SCS on request. The research team were available for consultation throughout the analysis process. MEM was consulted for content expertise and consensus.
Stamelou M, Hoeglinger GU. Atypical Parkinsonism: an update. Current Opinion Neurol. 2013; 26(4):
While there has been many researches on progressive supranuclear palsy (PSP), not many have been able to research the weakness of the mind and body. Many often forget how much the brain and body go hand and hand. Yet plenty do not even know what PSP is. Here today we will discuss what the disease is and how it effects your whole body not just the brain.
Progressive supranuclear palsy is a rare disease. This disease is so random; some cases run in families. While most try to figure out how PSP begin to get into their genetics, it is still unknown. Yet research say that it is due to the mutation to the MAPT (missed approach point) gene. Now what is our MAPT gene, this gene is so important that it should be talked about more. Our MAPT gene provides instructions for making a protein called tau. This important protein, tau, is throughout our nervous system. While typing it makes one wonder why aren’t more people interested in their brains? There are certain things that our brain needs to be able to function for us for a long time. While studies explore the responsiveness of the scales and minimally clinically significant change given that was infrequently addressed. Also being able to address the psychological reasoning behind the troubles of which the PSP patient has and the depression the caregivers have along with stress that comes with the family. It would be a huge help when it comes to caregivers if they had more knowledge on what is going on. It will always be stressful, but at least there could be some knowledge within the room. Even if one is not subject to get PSP, tau protein may seem so small, but it holds a big name because the association with multiple brain diseases.
In addition, most cognitive studies of PSP have been limited by small samples. (Steele JC). There are many tips on what to do and how to do things, so that if the disease it is taking your balance, moment, or may eyesight there are actives that can help keep one out of a depression state.
Steele JC, Richardson JC, Olszewski J. Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol 1964;10:333–359.
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